Systemic Homeostasis Control is the overarching regulatory function of the body to maintain internal stability across key physiological parameters, primarily mediated through complex, interacting endocrine feedback loops. This control ensures that variables like glucose concentration, core temperature, and fluid balance remain within narrow, viable limits despite external fluctuations. The endocrine system provides the primary chemical communication network for this essential governance.
Origin
This concept is central to physiology, originating from Walter Cannon’s work, but here it is specifically anchored to the hormonal mechanisms that govern internal constancy. It emphasizes the integrated nature of regulation.
Mechanism
Control operates via negative feedback loops where the output of a process inhibits its own upstream stimulus; for example, high circulating cortisol suppresses CRH and ACTH release. Positive feedback loops, though rarer, also exist to drive rapid physiological events, such as the LH surge during ovulation. Precise tuning of these feedback sensitivities is what maintains systemic equilibrium against daily physiological demands.
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