What is the Origin of Systemic Homeostasis Adjustment?

The concept builds upon Walter Cannon's original theory of homeostasis, which described the body's tendency toward a stable internal state. The term adjustment emphasizes the non-static, adaptive nature of this process, particularly under persistent stress or therapeutic intervention, aligning with the more modern concept of allostasis. It recognizes that chronic physiological changes necessitate a systemic re-tuning of regulatory mechanisms for survival.

What is the Mechanism of Systemic Homeostasis Adjustment?

The adjustment mechanism is orchestrated by the central neuroendocrine axes, particularly the HPA axis and the autonomic nervous system. These systems sense deviations from the optimal set-points and initiate corrective feedback loops, involving the release of hormones like cortisol, thyroid hormone, and catecholamines. Successful adjustment results in a new, stable physiological state that is better suited to the prevailing environmental demands, preventing the breakdown of critical metabolic and hormonal functions and preserving long-term health.

Systemic Homeostasis Adjustment ∞ Area

Systemic Homeostasis Adjustment

Meaning

Systemic homeostasis adjustment is the dynamic, coordinated physiological process by which the entire organism re-calibrates its internal environment in response to chronic internal or external challenges to maintain stable functioning. This complex process involves the integrated regulation of multiple interconnected systems, including the endocrine, nervous, and immune systems. The adjustment is an adaptive shift in the set-points of physiological variables, aiming for allostasis rather than a static equilibrium.