What is the Origin of Systemic Growth Factor Upregulation?

This phrase extends the concept of growth factor modulation from a cellular level to encompass the entire physiological system, often involving the liver as a central endocrine organ for mediators like IGF-1. Systemic implies widespread effect.

What is the Mechanism of Systemic Growth Factor Upregulation?

Systemic upregulation is frequently achieved through optimizing pituitary function to release pulsatile growth hormone, which then stimulates hepatic synthesis and secretion of IGF-1 into the circulation. Proper nutrient support ensures the liver has the necessary substrates to execute this systemic anabolic signaling.

Systemic Growth Factor Upregulation ∞ Area

Systemic Growth Factor Upregulation

Meaning

The broad, whole-body enhancement of signaling molecules, like Insulin-like Growth Factor 1 (IGF-1) or various interleukins, that promote tissue maintenance, repair, and anabolic processes throughout multiple physiological compartments. This contrasts with localized upregulation.