What is the Origin of Systemic Gains?

This concept is derived from systems theory applied to human biology, emphasizing that the whole system response is greater than the sum of its individual parts. It contrasts with siloed treatment approaches, advocating for holistic optimization where improvements in one area support others.

What is the Mechanism of Systemic Gains?

The mechanism is often mediated through the resolution of chronic low-grade inflammation or the normalization of key endocrine signaling cascades, such as the insulin/IGF axis. For example, improving visceral fat profile reduces inflammatory adipokine release, which in turn enhances peripheral insulin receptor sensitivity and may positively influence gonadal hormone output. This interconnected feedback loop drives widespread functional enhancement.

Systemic Gains

Meaning

Systemic Gains represent broad, interconnected improvements across multiple physiological systems resulting from a targeted intervention, rather than isolated improvements in a single metric. In hormonal health, this implies positive shifts in body composition, improved insulin sensitivity, enhanced cardiovascular function, and stabilized mood, all reinforcing one another. These gains reflect true physiological synergy.