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Systemic Fidelity Loss

Meaning

A progressive, measurable decline in the precision, responsiveness, and coordinated function of the body’s major homeostatic and regulatory systems, including the endocrine feedback loops, autonomic nervous system control, and cellular signaling pathways. This loss of ‘fidelity’ is characterized by increased biological variability, reduced adaptive capacity to stressors, and a widening gap between optimal and actual physiological parameters, representing a core aspect of biological aging. It is a failure of complex biological communication.