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Systemic Fatigue Measurement

Meaning

Systemic Fatigue Measurement is the objective, multi-modal assessment of exhaustion that results from a cumulative physiological burden impacting multiple organ systems, distinguishing it from simple muscular tiredness. This measurement integrates subjective patient reporting with objective clinical data, including hormonal profiles (e.g., HPA axis status), inflammatory markers, mitochondrial function indicators, and autonomic nervous system metrics. The resulting data provides a clear, evidence-based understanding of the deep-seated biological mechanisms contributing to chronic fatigue states. This comprehensive approach is essential for effective therapeutic targeting.