The active clinical endeavor to minimize the accumulation of molecular damage, functional disorganization, and metabolic inefficiency across the body’s integrated systems, thereby actively counteracting the thermodynamic drive toward aging and decline. This process seeks to restore order and efficiency at the cellular and tissue levels. It is a direct biological strategy against physiological decay. We measure success by biomarker improvements.
Origin
This framework applies concepts from thermodynamics to biology, where aging is viewed as an increase in systemic entropy or disorder. Wellness strategies are then framed as energy-intensive processes that locally reduce this disorder. It signifies a proactive fight against the natural tendency toward disorganization in complex biological systems. This is a high-level conceptualization of longevity.
Mechanism
Entropy reduction is mechanistically achieved by upregulating cellular housekeeping processes like autophagy to clear damaged proteins and organelles. Enhancing mitochondrial function reduces the production of reactive oxygen species, a major source of molecular damage. Furthermore, by supporting robust endocrine signaling, the body maintains better structural integrity and repair capabilities, resisting the slide toward chaos.
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