Skip to main content

Systemic Energy Dysregulation

Meaning

Systemic energy dysregulation refers to a widespread pathological imbalance in the body’s processes for generating, storing, and utilizing metabolic energy across various organ systems, which is often centrally mediated by dysfunctional hormonal signaling. This condition is characterized by inefficiencies in mitochondrial function, altered substrate partitioning between fat and glucose, and a breakdown in the communication between key metabolic tissues like the liver, muscle, and adipose tissue. Hormones such as insulin, thyroid hormone, and leptin are frequently implicated in this dysregulation, leading to clinical manifestations like chronic fatigue, weight gain, and insulin resistance. It represents a fundamental failure in the body’s capacity to maintain energy homeostasis.