What is the Origin of Systemic Dysregulation Markers?

This concept arises from the field of systems biology and functional medicine, where health is viewed as the dynamic balance of interconnected networks, not just the absence of disease. The focus on "dysregulation" rather than specific pathology allows for the early identification of individuals at high risk for future chronic illness. The markers are utilized to track the progression of biological decline and the efficacy of preventative interventions.

What is the Mechanism of Systemic Dysregulation Markers?

Key markers include elevated C-reactive protein (CRP) and interleukins (IL-6), which indicate chronic inflammation, and high fasting insulin or HbA1c, reflecting metabolic dysregulation and insulin resistance. Hormonal markers, such as an inverted or flattened cortisol diurnal curve or low free testosterone, signal HPA or HPG axis exhaustion. Collectively, these markers demonstrate a failure of the body's adaptive mechanisms to maintain stability, leading to accelerated cellular senescence and organ damage.

Systemic Dysregulation Markers ∞ Area

Systemic Dysregulation Markers

Meaning

Systemic Dysregulation Markers are a panel of measurable biochemical, physiological, or genetic indicators that collectively signal a breakdown in the body’s overall homeostatic control and adaptive capacity across multiple organ systems. These markers extend beyond single-disease diagnostics to include indicators of chronic inflammation, metabolic inefficiency, oxidative stress, and impaired hormonal feedback loops. They serve as objective evidence of allostatic load and biological aging.