What is the Origin of Systemic Dysregulation Cascade?

This clinical concept combines "systemic," meaning affecting the entire body, with "dysregulation," denoting a loss of control, and "cascade," a metaphor for a rapidly multiplying series of events. It is a core concept in systems biology and functional medicine. The term emphasizes the interconnectedness of all bodily functions.

What is the Mechanism of Systemic Dysregulation Cascade?

A common cascade begins with chronic stress-induced adrenal dysregulation, leading to cortisol resistance. This then impairs glucose metabolism, contributing to insulin resistance, which subsequently affects sex hormone binding globulin (SHBG) and gonadal hormone balance. The mechanism illustrates how a single point of failure can destabilize the entire homeostatic network, resulting in widespread inflammation and accelerated aging.

Systemic Dysregulation Cascade ∞ Area

Systemic Dysregulation Cascade

Meaning

Systemic Dysregulation Cascade is a sequence of interconnected physiological failures where an initial imbalance in one major regulatory system, such as the endocrine or metabolic network, triggers subsequent, progressive dysfunction in other seemingly unrelated systems. This cascading effect leads to a state of chronic, generalized health decline that is often complex and difficult to isolate to a single root cause. It is a hallmark of advanced, unaddressed hormonal and metabolic stress.