What is the Origin of Systemic Degradation Resistance?

This concept is central to gerontology and the biology of aging, where degradation is understood as the progressive loss of molecular fidelity and tissue function over time. The term emphasizes the body's natural defense systems against this decline, seeking to enhance them through clinical intervention. It highlights the protective power of endogenous biological processes.

What is the Mechanism of Systemic Degradation Resistance?

Resistance is mediated by fundamental cellular processes, including DNA repair, proteostasis (protein quality control), and autophagy, which clear damaged cellular components. Hormones, such as DHEA and growth hormone, play a crucial regulatory role by promoting anabolic pathways and reducing chronic catabolism. The clinical goal is to support these intrinsic mechanisms to fortify the entire system against decline.

Systemic Degradation Resistance

Meaning

Systemic Degradation Resistance is the intrinsic biological capacity of the entire organism to withstand and effectively counteract the cumulative damaging effects of aging, oxidative stress, and chronic inflammation across all major organ systems. A high level of resistance signifies robust cellular repair mechanisms, efficient waste removal, and stable hormonal regulation. This resistance is a core measure of biological longevity.