Systemic Degradation Prevention is a comprehensive, proactive clinical strategy focused on mitigating the cumulative cellular and molecular damage that drives age-related decline and chronic disease across all major organ systems. It involves targeted interventions to address the hallmarks of aging, such as telomere attrition, genomic instability, and cellular senescence. The goal is to maintain the functional integrity of the body’s systems, thereby preventing the onset of age-related systemic decline and preserving healthspan.
Origin
The concept is a core tenet of modern longevity medicine, directly addressing the mechanistic theories of aging, which view aging as a process of cumulative degradation rather than an inevitable fate. “Prevention” in this context is active and targeted, utilizing scientific advancements to interrupt the pathological cascade. The term is rooted in the clinical desire to compress morbidity and extend the period of healthy life.
Mechanism
Prevention is mechanistically achieved by employing therapies that enhance endogenous repair pathways and neutralize damaging factors. This includes optimizing hormone levels to support anabolic processes, utilizing senolytics to clear senescent cells, and administering specific compounds to enhance DNA repair mechanisms. By continuously supporting cellular maintenance and regeneration, the body’s overall functional reserve is preserved, effectively preventing premature systemic breakdown.
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