Systemic De-Flammation refers to the clinical process of actively reducing and resolving chronic, low-grade, body-wide inflammation, which is a key driver of aging and nearly all non-communicable diseases. This state is achieved by identifying and eliminating underlying inflammatory triggers, such as gut dysbiosis, chronic infections, or dietary antigens, and implementing targeted anti-inflammatory therapies. The successful achievement of de-flammation is clinically verified by a sustained reduction in circulating inflammatory biomarkers like high-sensitivity C-reactive protein (hs-CRP).
Origin
This term is a modern clinical construct, combining the concept of a body-wide process (‘Systemic’) with the active reduction of inflammation (‘De-Flammation’). ‘Inflammation’ is derived from the Latin inflammatio (to set on fire). The prefix ‘De-‘ signifies the reversal or removal of this pathological process. The term reflects the growing clinical focus on chronic inflammation, often termed “inflammaging,” as a central, modifiable pathway in longevity medicine.
Mechanism
The mechanism operates by first removing the persistent stimuli that activate the innate immune system, such as poor diet or unmanaged stress. Concurrently, targeted interventions, including specific omega-3 fatty acids, polyphenols, and hormonal balance, are deployed to modulate inflammatory signaling pathways, like NF-kappaB. This comprehensive strategy shifts the body’s internal milieu from a pro-inflammatory to a pro-resolving state, thereby facilitating tissue repair and reducing the cumulative damage associated with chronic immune activation.
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