A clinical diagnostic process focused on identifying the single, primary limiting factor or bottleneck within an individual’s complex physiological network that is disproportionately hindering overall health, performance, or longevity. This isolation is crucial for prioritizing therapeutic interventions to achieve the greatest systemic benefit. It applies the principle of constraints to human physiology.
Origin
A term derived from systems thinking and clinical diagnostics, applying the concept of “Constraint,” a limiting factor, to the entire body, “Systemic,” and the process of “Isolation,” identifying the root cause. It is a methodology for root-cause analysis in functional medicine.
Mechanism
The isolation mechanism involves a comprehensive analysis of interconnected biological systems, including the endocrine, metabolic, and immune axes, often using advanced biomarker panels. For example, if a patient exhibits low energy, the constraint might be isolated to low free T3 (thyroid), high reverse T3, or severe mitochondrial dysfunction, allowing the clinician to target the root systemic limitation rather than merely treating the symptom of fatigue.
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