Systemic Communication Clarity refers to the fidelity and efficiency with which the endocrine, nervous, and immune systems exchange regulatory information throughout the entire organism. High clarity implies that hormonal signals are transmitted, received, and acted upon without significant degradation, interference, or noise from inflammatory or metabolic stressors. It is the measure of integrated physiological coherence.
Origin
This is a functional term combining “systemic,” relating to the whole body, with “communication clarity,” emphasizing the quality of information exchange. Its importance arises when considering chronic conditions where crosstalk between systems, such as the gut-brain-adrenal axis, becomes impaired. We use this concept to assess overall network health.
Mechanism
The mechanism relies on unimpaired receptor expression, balanced circulating levels of messengers, and minimal signal blockade by antagonists or inflammatory cytokines. For instance, chronic inflammation can introduce noise, dampening the efficacy of insulin signaling despite adequate circulating levels, thus reducing clarity. Restoring clarity often involves reducing systemic inflammation to allow native hormonal signals to propagate effectively.
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