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Systemic Command Failure

Meaning

This is a conceptual term used to describe a critical breakdown in the central regulatory capacity of the body’s primary control systems, typically involving the neuroendocrine axis, which leads to a widespread inability to maintain physiological homeostasis. It represents a state where the command centers—such as the hypothalamus and pituitary—fail to generate or properly coordinate the necessary hormonal and neurological signals. The failure results in a cascading array of dysfunctions across multiple organ systems. This loss of central governance impairs systemic resilience.