What is the Origin of Systemic Catabolism Reversal?

This concept is fundamentally rooted in metabolic physiology and clinical nutrition, focusing on the balance between anabolism and catabolism, which dictates tissue turnover and body composition. The "reversal" highlights the clinical intervention necessary to counteract age-related or disease-induced protein wasting.

What is the Mechanism of Systemic Catabolism Reversal?

Reversal is mediated by optimizing the systemic ratio of anabolic to catabolic hormones, such as increasing the relative influence of Growth Hormone and testosterone while mitigating excessive cortisol signaling. Anabolic hormones stimulate the mammalian target of rapamycin (mTOR) pathway, enhancing protein synthesis and cellular proliferation. Simultaneously, these hormones suppress the ubiquitin-proteasome system, reducing protein degradation and thereby promoting a net accretion of lean tissue mass.

Systemic Catabolism Reversal

Meaning

Systemic Catabolism Reversal is the physiological shift from a predominantly catabolic (breakdown) state, characterized by the degradation of complex molecules like muscle protein and bone matrix, to an anabolic (building) state. This reversal is a core therapeutic goal in managing sarcopenia, frailty, and chronic illness, aiming to restore a positive nitrogen balance and promote tissue repair and regeneration. Hormonal signals, particularly those related to growth and sex steroids, are primary drivers of this anabolic shift.