What is the Origin of Systemic Baseline?

This term is derived from systems physiology and control theory, using 'systemic' to encompass the entire organism and 'baseline' to denote the reference point for all physiological fluctuations. In clinical practice, measuring this baseline is crucial for assessing chronic health status and the efficacy of therapeutic interventions. A disrupted baseline often signifies chronic underlying stress or disease.

What is the Mechanism of Systemic Baseline?

The maintenance of the systemic baseline is regulated by the autonomic nervous system and the endocrine system's negative feedback loops, ensuring narrow limits for vital parameters. Hormones like thyroid hormone set the overall metabolic rate, while the HPA axis controls the basal level of cortisol. A mechanism of robust homeostasis ensures that the body expends minimal energy to maintain this stable, low-entropy state, maximizing available resources for adaptive responses.

Systemic Baseline

Meaning

The Systemic Baseline refers to the stable, resting equilibrium state of all major physiological parameters, including core body temperature, resting heart rate, blood pressure, and circulating hormone concentrations. This baseline represents the body’s default, energy-efficient mode of operation when not under acute stress or engaged in demanding activity. A healthy, robust systemic baseline is indicative of optimal allostatic capacity and low allostatic load.