What is the Origin of Systemic Anti-Senescence?

This is a key concept in modern longevity medicine and cellular biology, directly addressing one of the recognized hallmarks of aging. The development of senolytic and senomorphic agents, compounds that selectively clear or suppress senescent cells, provided the therapeutic tools for this strategy. Clinical endocrinology recognizes that age-related hormonal decline can accelerate the accumulation of these cells.

What is the Mechanism of Systemic Anti-Senescence?

The strategy involves interventions designed to either selectively induce apoptosis in senescent cells or suppress their harmful SASP, thereby reducing chronic, low-grade systemic inflammation. Hormonal balance plays a supportive role, as optimal levels of hormones like growth hormone and DHEA promote cellular repair and reduce the oxidative stress that can trigger senescence. By clearing these dysfunctional cells, the strategy improves tissue microenvironments and enhances overall organ function.

Systemic Anti-Senescence ∞ Area

Systemic Anti-Senescence

Meaning

Systemic Anti-Senescence is a comprehensive clinical strategy aimed at mitigating the accumulation and detrimental effects of senescent, or aging, cells throughout the body’s tissues and organs. Senescent cells are metabolically active cells that stop dividing but resist apoptosis, instead secreting a pro-inflammatory profile known as the Senescence-Associated Secretory Phenotype (SASP). The goal is to reduce this cellular burden to promote tissue rejuvenation and extend healthspan.