What is the Origin of Systemic Anti-Inflammatory Signaling?

This concept evolved from immunology and endocrinology, recognizing that chronic, unresolved inflammation is a major driver of aging and pathology. The term highlights the active, regulatory nature of the anti-inflammatory response, moving beyond simple suppression to active resolution. It is a cornerstone of modern preventative medicine.

What is the Mechanism of Systemic Anti-Inflammatory Signaling?

The mechanism is heavily influenced by hormonal balance, as glucocorticoids like cortisol, when released rhythmically, act as potent anti-inflammatory agents. Furthermore, optimizing the ratio of omega-3 to omega-6 fatty acids provides the substrate for the synthesis of SPMs, which actively switch off the inflammatory cascade. Interventions focus on diet, exercise, and targeted supplementation to modulate the NF-kappa B pathway and shift the cellular environment toward resolution.

Systemic Anti-Inflammatory Signaling ∞ Area

Systemic Anti-Inflammatory Signaling

Meaning

Systemic Anti-Inflammatory Signaling refers to the body’s endogenous processes and therapeutic strategies aimed at promoting a state of low-grade, regulated inflammation, or resolving chronic, low-level inflammation often termed “inflammaging.” This signaling involves the coordinated release of anti-inflammatory cytokines, specialized pro-resolving mediators (SPMs), and the balanced activity of key regulatory hormones. Maintaining this anti-inflammatory state is crucial for preserving tissue integrity, metabolic health, and reducing the risk of age-related chronic diseases.