What is the Origin of Systemic Adaptation Threshold?

This concept is derived from the General Adaptation Syndrome and the Allostatic Load model, with "threshold" being a term from physics and engineering to denote a point of change. "Systemic" emphasizes that this limit is a whole-body measure, not isolated to a single organ or system. Clinically, identifying this threshold is crucial for preventative health.

What is the Mechanism of Systemic Adaptation Threshold?

The threshold is maintained by the integrated function of the HPA axis, the immune system, and the autonomic nervous system. When stressors are below the threshold, the system initiates a successful adaptive response, such as increased heat shock protein production. Once the threshold is breached, the chronic demand for stress hormones and inflammatory mediators depletes reserves, leading to persistent dysregulation and eventual failure of homeostatic mechanisms.

Systemic Adaptation Threshold ∞ Area

Systemic Adaptation Threshold

Meaning

Systemic Adaptation Threshold is the maximum level of cumulative physiological and psychological stress that an individual’s body can tolerate and successfully adapt to before transitioning into a state of allostatic overload or chronic dysregulation. This threshold is highly individualized and is determined by genetic predisposition, hormonal reserve, and current lifestyle factors. Exceeding this limit leads to a decline in functional capacity and an increased risk of disease.