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Systemic Adaptation Mitigation

Meaning

Systemic Adaptation Mitigation is a clinical strategy designed to prevent or minimize the body’s adverse counter-regulatory responses that often undermine the long-term success of therapeutic interventions, particularly those related to weight loss or hormonal manipulation. These unwanted adaptations, such as a drop in resting metabolic rate or a blunted hormonal feedback loop, are natural protective mechanisms. Mitigation involves proactive measures to sustain the initial positive physiological change without triggering the body’s defensive backlash.