Skip to main content

System Sensitivity Cycling

Meaning

System Sensitivity Cycling is a therapeutic strategy involving the intentional, intermittent withdrawal or modulation of a hormonal or signaling agent to prevent the desensitization and down-regulation of its corresponding receptors and downstream pathways. This cycling technique aims to maintain or restore the target tissue’s responsiveness, ensuring that the system remains highly sensitive to the therapeutic stimulus over the long term. It is a proactive approach to circumvent the common physiological adaptation known as tachyphylaxis, which diminishes the efficacy of continuous hormonal exposure. This strategy is critical for sustained success in personalized hormone optimization.