What is the Origin of System Resilience Engineering?

This term is borrowed from systems engineering, where resilience is the ability to absorb disturbance while retaining essential function, combined with biological systems. In hormonal health, it reflects a shift toward designing endocrine function for durability rather than just achieving a static target.

What is the Mechanism of System Resilience Engineering?

Resilience engineering in this context involves ensuring that multiple overlapping pathways can compensate if a primary regulatory axis falters, for example, ensuring adequate adrenal reserve even if the HPG axis is temporarily suppressed. This is achieved by optimizing cellular energy status and minimizing systemic inflammation, which otherwise consumes adaptive capacity. The system is engineered to handle variance without tipping into chronic dysfunction.

System Resilience Engineering

Meaning

System Resilience Engineering is the application of engineering principles to design and fortify biological systems, especially the endocrine network, against failure or significant perturbation from internal or external stressors. This approach focuses on building redundancy and adaptive capacity into homeostatic loops to ensure functional stability under duress. We aim to design robust biological architectures capable of weathering insults.