System Reset Protocol is a structured, time-limited clinical intervention designed to interrupt and reverse a state of chronic physiological dysregulation, such as HPA axis dysfunction or metabolic resistance. The protocol typically involves a strategic withdrawal or reduction of specific stressors, a targeted period of nutritional and lifestyle optimization, and the judicious use of compounds to re-sensitize receptors or restore endogenous feedback loops. The objective is to force the system back toward a state of primary homeostasis.
Origin
The term is an analogy borrowed from computer science, where a ‘reset’ is used to clear a dysfunctional state and restore default operational parameters. In a clinical context, it is a functional medicine concept applied to complex endocrine and metabolic networks that have become chronically maladapted. The ‘protocol’ emphasizes a defined, systematic sequence of therapeutic actions.
Mechanism
The mechanism often targets the HPA axis by temporarily reducing psychological and metabolic load, thereby lowering chronic cortisol exposure to allow for receptor upregulation and resensitization. In hormonal therapy, it may involve a brief cessation of exogenous hormones to allow the Hypothalamic-Pituitary axis to re-establish its own endogenous signaling rhythm. This intentional pause and re-introduction of balance aims to restore the system’s innate self-regulatory capacity.
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