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System Performance Envelope

Meaning

The System Performance Envelope is a clinical concept representing the measurable limits and capacity for adaptive function across an individual’s major physiological systems, including the cardiovascular, metabolic, and neuroendocrine axes. It defines the range of external and internal stressors an individual can effectively manage without compromising systemic homeostasis or inducing pathology. A broad, high-level envelope signifies robust physiological reserve, metabolic flexibility, and resilience to stress. Monitoring this envelope is crucial for proactive health management and for guiding interventions aimed at extending the healthspan.