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System-Level Depletion

Meaning

System-Level Depletion is a clinical descriptor for a profound, pervasive state of physiological deficit affecting multiple interconnected organ systems, often resulting from chronic, unmanaged stress, prolonged nutrient insufficiency, or persistent hormonal imbalance. This condition extends beyond the simple depletion of a single hormone or nutrient to involve a compromised functional reserve across the entire endocrine, metabolic, and immune architecture. The resulting lack of resilience manifests as chronic fatigue, impaired recovery, and accelerated biological aging.