What is the Origin of System Feedback Control?

This term is a core principle of cybernetics and control theory, applied directly to human physiology, particularly the endocrine system. The concept describes the essential regulatory architecture of the Hypothalamic-Pituitary-Gland axes (e.g., HPA, HPG, HPT), which have been studied extensively since the mid-20th century.

What is the Mechanism of System Feedback Control?

In negative feedback, high levels of a final hormone, such as cortisol or testosterone, act upon the pituitary and hypothalamus to suppress the release of their respective tropic or releasing hormones. Conversely, positive feedback, such as the surge of luteinizing hormone (LH) triggered by rising estrogen before ovulation, temporarily amplifies the signal. The integrity of this control mechanism is paramount for preventing hormonal excess or deficiency and is a key indicator of endocrine health.

System Feedback Control ∞ Area

System Feedback Control

Meaning

System Feedback Control is the fundamental homeostatic mechanism in endocrinology where the output of a hormonal pathway regulates its own upstream production. This intricate, self-regulating loop ensures that hormone concentrations remain within a narrow, physiological range necessary for stable systemic function. It is a dynamic process involving both negative feedback, which is inhibitory, and positive feedback, which is stimulatory.