System Design, in this context, refers to the overarching architecture of an individual’s regulatory networks, emphasizing the interconnected feedback mechanisms governing the endocrine, metabolic, and neurological axes.
Origin
Borrowed from engineering principles, it is applied here to conceptualize the integrated physiological structure of the human organism.
Mechanism
Effective system design ensures robust negative feedback loops within the HPT and HPA axes, allowing for rapid adaptation to environmental shifts while maintaining long-term endocrine stability.
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