What is the Origin of System Decay Targeting?

This concept is a cornerstone of geroscience, a field that seeks to understand the link between aging and age-related diseases. The term emphasizes a proactive, precision approach to longevity medicine. Targeting implies the use of highly specific therapeutic agents, such as senolytics or NAD+ precursors, to selectively interrupt the processes of systemic decline.

What is the Mechanism of System Decay Targeting?

The mechanism involves modulating specific pathways implicated in cellular aging. For instance, interventions may target the mTOR pathway to promote autophagy and cellular cleanup or utilize sirtuin activators to enhance DNA repair and metabolic efficiency. By reducing the burden of senescent cells and improving mitochondrial health, the body's overall bioenergetic state is optimized, which in turn supports robust endocrine signaling and tissue regeneration.

System Decay Targeting ∞ Area

System Decay Targeting

Meaning

System Decay Targeting is a clinical and research paradigm focused on identifying and intervening in the core biological processes that drive age-related decline and chronic disease. This strategy moves beyond symptom management to address fundamental mechanisms of senescence, such as telomere attrition, cellular senescence, and mitochondrial dysfunction. In hormonal health, targeting decay aims to preserve the functional capacity of endocrine glands and receptor sensitivity, thereby extending hormonal vitality.