Comprehensive, multi-faceted therapeutic strategies designed to exert broad, coordinated influence over multiple interconnected physiological systems, such as the neuroendocrine-immune-metabolic network. These interventions move beyond single-target drug therapy to address systemic dysfunctions that underlie chronic health decline. The goal is to restore harmonious function across the entire biological landscape.
Origin
A term from systems biology and complex adaptive systems theory, applied to clinical medicine to emphasize the interconnectedness of biological functions. It represents a paradigm shift from siloed organ-based treatment to holistic, network-level management. This approach acknowledges the complexity of the human body.
Mechanism
Involves the simultaneous application of precise hormonal, nutritional, lifestyle, and peptide-based therapies to modulate key regulatory nodes in the biological network. By targeting upstream controllers like the hypothalamus or mitochondrial function, a single intervention can generate beneficial downstream effects across multiple systems. This coordinated approach maximizes leverage for systemic health improvement.
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