System Control Biology is the integrative scientific discipline that examines the complex, multi-level regulatory networks—including the neuroendocrine, immune, and metabolic systems—that govern the body’s overall homeostatic stability and adaptive capacity. It views the organism not as a collection of isolated organs but as a highly interconnected, dynamic control system that continuously manages internal and external perturbations. The clinical goal derived from this biology is to identify and modulate the central regulatory nodes to restore optimal systemic function and resilience.
Origin
This concept is an extension of systems biology, applying control theory from engineering to the study of living organisms. It emerged from the realization that age-related decline and chronic diseases are often failures of inter-system communication and regulatory control, rather than isolated organ failures. This framework provides the intellectual foundation for understanding the complex interplay between neuroendocrine rhythms and cellular physiology.
Mechanism
The mechanism involves analyzing feedback loops, feed-forward mechanisms, and cross-talk between major regulatory axes, such as the Hypothalamic-Pit
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