System Architecture Review is a comprehensive clinical audit of the foundational regulatory networks of the human body, encompassing the neuroendocrine, metabolic, and immune systems, to identify points of inefficiency, chronic stress, or systemic drift. This review assesses the structural integrity and functional connectivity of the entire physiological system, moving beyond isolated symptom treatment to understand the root cause of functional decline. The objective is to map the patient’s unique physiological landscape to design an integrated, precision-based intervention strategy.
Origin
The term is a sophisticated metaphor borrowed from engineering and information technology, where ‘architecture review’ refers to the systematic examination of a complex system’s design and structure. In a clinical setting, it reflects a holistic, systems biology approach to health, acknowledging the interconnectedness of all regulatory systems. This review is foundational to modern functional medicine, which seeks to optimize the entire organism rather than just treating symptoms.
Mechanism
The review mechanism involves synthesizing data from advanced diagnostics, including hormone panels, metabolomics, and genetic markers, to create a functional map of the body’s control systems. It specifically looks for evidence of chronic low-grade inflammation, HPA axis dysregulation, or mitochondrial dysfunction, which represent critical points of failure in the system’s architecture. By identifying these systemic weak points, the clinician can implement targeted, upstream interventions that yield broad, cascading benefits across multiple organ systems.
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