Synaptogenesis Regulation is the complex, genetically and biochemically controlled process of forming new synapses, which are the functional connections between neurons in the nervous system. This continuous process is fundamental to learning, memory, and cognitive plasticity throughout the lifespan. Optimal regulation is crucial for maintaining neural network integrity and supporting robust cognitive function.
Origin
The term is central to developmental and cellular neuroscience. Synaptogenesis is a compound word from the Greek synapsis (junction) and genesis (creation). Regulation denotes the control of a process.
Mechanism
This process is mediated by a multitude of signaling molecules, including neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF) and specific cell adhesion molecules. Hormones, particularly estrogen and testosterone, act as powerful neuromodulators, influencing the expression of these growth factors and receptor density. Proper regulation ensures that synapses are formed and pruned efficiently, allowing the brain to adapt and reorganize in response to experience and environment.
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