Synaptogenesis Promotion is the clinical strategy focused on actively stimulating the formation of new synapses, the crucial communication junctions between neurons in the central nervous system. This process is fundamental to neuroplasticity, learning, memory consolidation, and overall cognitive resilience. Promoting synaptogenesis is a direct intervention aimed at reversing age-related decline in neuronal connectivity and enhancing brain functional reserve.
Origin
The term is a compound of the Greek synapsis (junction) and genesis (creation), originating in developmental neuroscience and later becoming a key therapeutic target in adult neurobiology and regenerative medicine.
Mechanism
Promotion is primarily mediated by neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), which bind to their respective receptors to activate intracellular signaling cascades that regulate gene expression for synaptic proteins. Certain hormones, including estrogen and testosterone, also directly or indirectly modulate the expression and activity of these neurotrophic factors, thereby supporting the structural and functional integrity of neuronal circuits.
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