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Synaptic Scaffolding Integrity

Meaning

Synaptic Scaffolding Integrity refers to the structural and functional soundness of the complex protein matrix that anchors neurotransmitter receptors and signaling molecules at the post-synaptic terminal. This physical scaffolding is essential for maintaining the precise geometry and signaling efficiency of the synapse, which is the fundamental unit of neural communication. Compromised integrity is directly linked to impaired cognitive function and reduced neuroplasticity.