What is the Origin of Synaptic Plasticity Maintenance?

This term comes from neuroscience, where plasticity describes the brain's ability to reorganize itself by forming new neural connections throughout life. Maintenance addresses the age-related challenge to this inherent ability.

What is the Mechanism of Synaptic Plasticity Maintenance?

Optimal maintenance is supported by adequate levels of neurosteroids, particularly allopregnanolone and estrogens, which modulate GABAergic and NMDA receptor function, respectively. Furthermore, growth factors like BDNF, often upregulated by anabolic states, directly promote dendritic spine stability and synaptogenesis. Maintaining hormonal balance is therefore foundational to preserving this essential neural function.

Synaptic Plasticity Maintenance

Meaning

Synaptic Plasticity Maintenance is the physiological process ensuring the strength and adaptability of neuronal connections remain robust, allowing for continuous learning, memory consolidation, and cognitive flexibility. This maintenance is critically dependent on a stable, supportive neuroendocrine environment. We aim to preserve the brain’s capacity for structural adaptation.