Skip to main content

Synaptic Maintenance Signals

Meaning

Synaptic Maintenance Signals are the diverse array of neurotrophic factors, hormones, and local signaling molecules that govern the structural integrity, functional plasticity, and long-term viability of neuronal synapses in the central nervous system. These signals are fundamentally crucial for high-level cognitive processes, including learning, memory consolidation, and overall neural network function. Deficiencies in the strength or timing of these signals are implicated in age-related cognitive decline and the progression of neurodegenerative processes. Optimal hormonal balance, particularly neurosteroid and thyroid hormone sufficiency, is a key determinant of the strength of these maintenance signals.