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Synaptic Debris Scavenging

Meaning

Synaptic Debris Scavenging is the specialized, continuous process by which glial cells, primarily microglia and astrocytes, actively clear away damaged, dysfunctional, or unnecessary synaptic components and extracellular waste products from the neural environment. This crucial maintenance function is essential for preserving the integrity of neural circuits, promoting optimal synaptic plasticity, and preventing the accumulation of neurotoxic protein aggregates. Efficient scavenging is a hallmark of a healthy, young brain and is critical for sustained cognitive function and robust protection against neurodegenerative diseases. Impairment in this process is a key factor in accelerated brain aging.