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Symptomatic Hypogonadism

Meaning

Symptomatic Hypogonadism is a formal clinical diagnosis characterized by measurably low circulating levels of sex hormones, such as testosterone or estradiol, that are directly correlated with the presence of specific, attributable physical, emotional, and cognitive symptoms. This pathological state reflects a failure of the gonads or a dysfunction of the Hypothalamic-Pituitary-Gonadal (HPG) axis, resulting in insufficient sex steroid production, which manifests as decreased libido, profound fatigue, mood disturbance, and loss of lean body mass. The definitive diagnosis relies on the clear clinical correlation between the biochemical deficiency and the patient’s lived experience of functional decline.