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Symptom-Driven Dose Titration

Meaning

Symptom-Driven Dose Titration is a patient-centric adjustment strategy in hormone therapy where changes to the prescribed dosage are guided primarily by the resolution or persistence of the patient’s clinical symptoms, such as fatigue, mood changes, hot flashes, or libido decline. While objective quantitative biomarker tracking provides the necessary safety parameters and physiological context, the patient’s subjective experience remains the ultimate arbiter of therapeutic success. This method acknowledges that optimal hormone levels vary significantly among individuals, emphasizing the personalized nature of treatment. It balances laboratory science with clinical reality.