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Symptom-Driven Dose Adjustment

Meaning

Symptom-Driven Dose Adjustment is a clinical methodology in personalized medicine, particularly for hormone replacement therapy, where the precise titration of a therapeutic dose is guided primarily by the patient’s subjective experience and the clinical resolution of their symptoms, rather than relying solely on fixed laboratory biomarker ranges. This approach explicitly acknowledges the high inter-individual variability in receptor sensitivity, metabolic clearance rates, and tissue-specific needs. It integrates accurate patient-reported outcomes as a critical, non-negotiable data point alongside objective lab results for the final fine-tuning of treatment.