What is the Origin of Sympathetic Cholinergic System?

This classification is a precise anatomical and pharmacological distinction within neurophysiology, challenging the simple generalization that all sympathetic postganglionic neurons are adrenergic. The system highlights the complex, nuanced integration of the autonomic nervous system. It is a specialized adaptation for human thermoregulation.

What is the Mechanism of Sympathetic Cholinergic System?

Preganglionic neurons originating in the thoracic spinal cord synapse in the sympathetic ganglia, and the postganglionic fibers then travel to the eccrine sweat glands. At the gland, these fibers release acetylcholine, which acts on muscarinic receptors to stimulate sweat production. This rapid, widespread activation of evaporative cooling mechanisms is critical for maintaining core body temperature during intense exercise or heat exposure.

Sympathetic Cholinergic System ∞ Area

Sympathetic Cholinergic System

Meaning

The Sympathetic Cholinergic System is a specific, unique efferent pathway within the sympathetic division of the autonomic nervous system that utilizes acetylcholine (ACh) as its postganglionic neurotransmitter, rather than the typical norepinephrine. This system is anatomically sympathetic but functionally cholinergic. Its primary physiological role is to govern the precise, rapid control of sweat gland secretion in response to thermal or emotional stimuli.