A dynamic, long-term physiological state characterized by the consistent maintenance of homeostatic balance across endocrine, metabolic, and inflammatory parameters, ensuring the body operates reliably at a high functional capacity over the lifespan. This is distinct from transient periods of feeling well; it requires continuous, adaptive regulation against ongoing environmental and internal challenges. It represents the successful integration of optimized biomarkers.
Origin
This concept arises from longevity science and chronic disease prevention, signifying the desired endpoint of successful health management that prevents the slide into subclinical dysfunction or overt pathology. Its origin lies in shifting the focus from acute treatment to enduring physiological stability. Sustained implies an active, ongoing process of maintenance.
Mechanism
Sustained wellness relies on the robust function of negative feedback loops, particularly within the HPA axis and the insulin signaling pathway, to rapidly correct minor deviations before they become entrenched imbalances. Effective internal timers ensure that critical anabolic and restorative processes occur optimally during designated periods. The mechanism is characterized by high physiological adaptability and low allostatic load accumulation over time.
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