What is the Origin of Sustained Synaptic Transmission?

This term is rooted in cellular neurophysiology, specifically the study of synaptic plasticity and fatigue, where the limits of continuous communication are investigated. The concept highlights the energetic and structural requirements necessary to maintain the fundamental process of chemical communication between neurons under demanding conditions. It underscores the metabolic dependency of neurological function.

What is the Mechanism of Sustained Synaptic Transmission?

Sustained transmission is dependent on the continuous replenishment of the readily releasable pool of synaptic vesicles and the efficient recycling of these vesicles via endocytosis to maintain the neurotransmitter supply. Adequate ATP is required to power the calcium pumps that

Sustained Synaptic Transmission ∞ Area

Sustained Synaptic Transmission

Meaning

Sustained Synaptic Transmission is the physiological capacity of a synapse to maintain the efficient and reliable release of neurotransmitters and subsequent postsynaptic response over a prolonged period of high-frequency neuronal activity. This ability is crucial for long-term information processing, learning, and the functional integrity of complex neural circuits. Failure to sustain transmission leads to synaptic fatigue and impaired cognitive function. The endurance of this process is a key measure of synaptic health.