What is the Origin of Sustained-Release Preparations?

This is a term from pharmaceutical science, combining "sustained," meaning to maintain or prolong, with "release," referring to the liberation of the active ingredient, and "preparations," indicating the formulated drug product. The technology was developed to improve patient compliance and optimize drug efficacy by controlling pharmacokinetic parameters.

What is the Mechanism of Sustained-Release Preparations?

The sustained-release mechanism is achieved through various formulation techniques, including embedding the active compound in a matrix of slowly dissolving polymers or coating the drug particles with a semi-permeable membrane. These barriers physically control the rate at which gastrointestinal fluids can penetrate the dosage form or the rate at which the active substance can diffuse out. The resulting slow dissolution rate ensures a gradual absorption into the bloodstream over many hours.

Sustained-Release Preparations ∞ Area

Sustained-Release Preparations

Meaning

Sustained-release preparations are pharmaceutical dosage forms engineered to release a therapeutic agent, such as a hormone or medication, into the body over an extended period of time following administration. The primary clinical goal is to maintain a relatively constant, therapeutic concentration of the active compound in the systemic circulation, thereby reducing dosing frequency and minimizing the peaks and troughs associated with immediate-release formulations. This controlled delivery is often preferred for hormones that naturally exhibit steady-state or specific diurnal rhythms.