What is the Origin of Sustained Release?

The term is a descriptive pharmaceutical engineering concept, combining 'sustained,' meaning maintained continuously, and 'release,' referring to the delivery of the active agent. The development of sustained-release technologies revolutionized drug administration by improving patient compliance and reducing the frequency of dosing while minimizing side effects associated with high peak concentrations.

What is the Mechanism of Sustained Release?

The mechanism involves incorporating the active compound into a matrix, coating, or reservoir system that controls the rate of dissolution or diffusion of the drug. For oral formulations, this often uses specialized polymers that slowly dissolve or swell in the gastrointestinal tract, ensuring a zero-order release kinetic. This controlled dissolution ensures that the hormone is delivered at a consistent rate, providing stable blood levels that more closely mirror natural physiology.

Sustained Release

Meaning

A pharmaceutical design principle for a drug delivery system that is engineered to release a therapeutic agent into the body slowly and continuously over an extended period of time. This controlled delivery contrasts with the rapid peak and trough effect of immediate-release formulations, aiming to maintain steady-state drug concentrations within the therapeutic window. In hormonal health, this is crucial for mimicking the body’s natural, consistent hormone secretion patterns.

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