What is the Origin of Sustained Pulsatile Release?

This concept is fundamental to neuroendocrinology, where the Greek word 'pulsus' meaning stroke or beat informs the term 'pulsatile.' 'Sustained' implies that these pulses occur reliably over long durations, mimicking natural endocrine rhythms. It contrasts sharply with exogenous, continuous infusion methods.

What is the Mechanism of Sustained Pulsatile Release?

The mechanism relies on central neuroendocrine oscillators that regulate the release machinery in the pituitary or hypothalamus. For example, the pulsatile release of GnRH dictates the subsequent pulsatile release of LH and FSH, which in turn drives ovarian or testicular function. Maintaining this natural oscillation is crucial for preventing receptor desensitization and preserving the target gland's responsiveness.

Sustained Pulsatile Release ∞ Area

Sustained Pulsatile Release

Meaning

Sustained Pulsatile Release describes the physiological pattern where hormones, particularly gonadotropins (like LH/FSH) and growth hormone, are secreted in rhythmic, intermittent bursts rather than as a continuous infusion. This specific pattern is essential because the receptors often become desensitized or downregulated by constant exposure to the hormone. The periodicity itself is a key component of the signal.