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Sustained Peak

Meaning

Sustained peak, in the context of pharmacokinetics and endocrinology, describes the maintenance of a drug concentration or a physiological response at or very near its maximum effective level for a prolonged and continuous duration. This characteristic is highly desirable in hormonal therapy, where consistent, stable receptor saturation is often necessary to achieve a reliable therapeutic effect without the negative physiological consequences of transient high and low fluctuations. Achieving a sustained peak is the primary goal of specific drug formulations, such as depot injections or transdermal patches, which are engineered for prolonged, controlled release kinetics. It is a critical metric for optimizing the efficacy and safety of chronic hormonal interventions.