The long-term, stable maintenance of optimal metabolic parameters, including stable blood glucose, healthy lipid profiles, and ideal body composition, achieved through the robust regulation of hormonal and nutrient-sensing pathways. This state signifies high metabolic flexibility and a reduced risk of chronic metabolic diseases. It is the antithesis of the yo-yo effect often seen with transient dietary changes.
Origin
This concept is a clinical goal in endocrinology and diabetology, emphasizing the durability of healthy metabolic regulation. “Sustained” underscores the need for continuous, resilient biological governance over time, moving beyond acute intervention.
Mechanism
Control is primarily mediated by maintaining high peripheral tissue insulin sensitivity and a balanced release of counter-regulatory hormones. Adipose tissue health is paramount, as dysfunctional fat cells contribute to systemic insulin resistance. Lifestyle interventions and targeted nutraceuticals work to stabilize the expression of glucose transporters and enhance mitochondrial function, ensuring that fuel is consistently partitioned and utilized appropriately across all energy demands.
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